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Raman-based system for DNA sequencing-mapping and other separations

Patent ·
OSTI ID:869250
 [1]
  1. Knoxville, TN
+ Show Author Affiliations
DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated.
Research Organization:
LOCKHEED MARTIN ENRGY SYST INC
DOE Contract Number:
AC05-84OR21400
Assignee:
Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)
Patent Number(s):
US 5306403
OSTI ID:
869250
Country of Publication:
United States
Language:
English

References (5)

Direct analysis of high-performance thin-layer chromatography spots of nucleic purine derivatives by surface-enhanced Raman scattering spectrometry journal February 1987
Determination of purine bases by reversed-phase high-performance liquid chromatography using real-time surface-enhanced Raman spectroscopy journal March 1991
Surface-enhanced Raman spectroscopy at a silver electrode as a detection system in flowing streams journal April 1990
Flow-injection analysis and real-time detection of RNA bases by surface-enhanced Raman spectroscopy journal September 1990
Surface-enhanced resonance Raman spectra of adriamycin, 11-deoxycarminomycin, their model chromophores, and their complexes with DNA journal November 1986

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