Raman-based system for DNA sequencing-mapping and other separations
Patent
·
OSTI ID:869250
- Knoxville, TN
DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated.
- Research Organization:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-84OR21400
- Assignee:
- Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)
- Patent Number(s):
- US 5306403
- OSTI ID:
- 869250
- Country of Publication:
- United States
- Language:
- English
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raman-based
dna
sequencing-mapping
separations
sequencing
mapping
performed
raman
spectrometer
surface
enhanced
scattering
sers
substrate
enhance
signal
label
attached
fragment
analyzed
identify
according
characteristics
spectrum
generated
sers label
raman scattering
dna sequencing
enhanced raman
surface enhanced
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raman spectrum
raman signal
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dna
sequencing-mapping
separations
sequencing
mapping
performed
raman
spectrometer
surface
enhanced
scattering
sers
substrate
enhance
signal
label
attached
fragment
analyzed
identify
according
characteristics
spectrum
generated
sers label
raman scattering
dna sequencing
enhanced raman
surface enhanced
dna fragment
raman spectrum
raman signal
/204/73/