Interface for liquid chromatograph-mass spectrometer

Patent · Sat Dec 31 23:00:00 EST 1988

OSTI ID:867111

Andresen, Brian D ^[1]; Fought, Eric R ^[2]

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1. Pleasanton, CA
2. Livermore, CA

A moving belt interface for real-time, high-performance liquid chromatograph (HPLC)/mass spectrometer (MS) analysis which strips away the HPLC solvent as it emerges from the end of the HPLC column and leaves a residue suitable for mass-spectral analysis. The interface includes a portable, stand-alone apparatus having a plural stage vacuum station, a continuous ribbon or belt, a drive train magnetically coupled to an external drive motor, a calibrated HPLC delivery system, a heated probe tip and means located adjacent the probe tip for direct ionization of the residue on the belt. The interface is also capable of being readily adapted to fit any mass spectrometer.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA
• DOE Contract Number: W-7405-ENG-48
• Assignee: Sepragen Corporation (San Leandro, CA)
• Patent Number(s): US 4867947
• OSTI ID: 867111
• Country of Publication: United States
• Language: English

Related Subjects

/422/250/436/
adapted
adjacent
analysis
apparatus
belt
calibrated
capable
chromatograph
chromatograph-mass
chromatograph-mass spectrometer
column
continuous
coupled
delivery
direct
drive
drive motor
drive train
emerges
external
fit
heated
high-performance
hplc
hplc column
interface
ionization
leaves
liquid
liquid chromatograph
located
located adjacent
magnetically
magnetically coupled
mass
mass spectrometer
mass-spectral
means
means located
motor
moving
performance liquid
plural
portable
probe
probe tip
readily
real-time
residue
ribbon
solvent
spectral analysis
spectrometer
stage
stand-alone
station
strips
suitable
tip
train
vacuum