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Title: Interface for liquid chromatograph-mass spectrometer

Abstract

A moving belt interface for real-time, high-performance liquid chromatograph (HPLC)/mass spectrometer (MS) analysis which strips away the HPLC solvent as it emerges from the end of the HPLC column and leaves a residue suitable for mass-spectral analysis. The interface includes a portable, stand-alone apparatus having a plural stage vacuum station, a continuous ribbon or belt, a drive train magnetically coupled to an external drive motor, a calibrated HPLC delivery system, a heated probe tip and means located adjacent the probe tip for direct ionization of the residue on the belt. The interface is also capable of being readily adapted to fit any mass spectrometer.

Inventors:
 [1];  [2]
  1. (Pleasanton, CA)
  2. (Livermore, CA)
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
867111
Patent Number(s):
US 4867947
Assignee:
Sepragen Corporation (San Leandro, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
interface; liquid; chromatograph-mass; spectrometer; moving; belt; real-time; high-performance; chromatograph; hplc; mass; analysis; strips; solvent; emerges; column; leaves; residue; suitable; mass-spectral; portable; stand-alone; apparatus; plural; stage; vacuum; station; continuous; ribbon; drive; train; magnetically; coupled; external; motor; calibrated; delivery; heated; probe; tip; means; located; adjacent; direct; ionization; capable; readily; adapted; fit; performance liquid; liquid chromatograph; chromatograph-mass spectrometer; spectral analysis; probe tip; mass spectrometer; located adjacent; magnetically coupled; drive motor; drive train; means located; hplc column; /422/250/436/

Citation Formats

Andresen, Brian D., and Fought, Eric R. Interface for liquid chromatograph-mass spectrometer. United States: N. p., 1989. Web.
Andresen, Brian D., & Fought, Eric R. Interface for liquid chromatograph-mass spectrometer. United States.
Andresen, Brian D., and Fought, Eric R. Sun . "Interface for liquid chromatograph-mass spectrometer". United States. https://www.osti.gov/servlets/purl/867111.
@article{osti_867111,
title = {Interface for liquid chromatograph-mass spectrometer},
author = {Andresen, Brian D. and Fought, Eric R.},
abstractNote = {A moving belt interface for real-time, high-performance liquid chromatograph (HPLC)/mass spectrometer (MS) analysis which strips away the HPLC solvent as it emerges from the end of the HPLC column and leaves a residue suitable for mass-spectral analysis. The interface includes a portable, stand-alone apparatus having a plural stage vacuum station, a continuous ribbon or belt, a drive train magnetically coupled to an external drive motor, a calibrated HPLC delivery system, a heated probe tip and means located adjacent the probe tip for direct ionization of the residue on the belt. The interface is also capable of being readily adapted to fit any mass spectrometer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}

Patent:

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