Interface for liquid chromatograph-mass spectrometer

Patent · Sun Jan 01 00:00:00 EST 1989

OSTI ID:867111

Andresen, Brian D ^[1]; Fought, Eric R ^[2]

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1. Pleasanton, CA
2. Livermore, CA

A moving belt interface for real-time, high-performance liquid chromatograph (HPLC)/mass spectrometer (MS) analysis which strips away the HPLC solvent as it emerges from the end of the HPLC column and leaves a residue suitable for mass-spectral analysis. The interface includes a portable, stand-alone apparatus having a plural stage vacuum station, a continuous ribbon or belt, a drive train magnetically coupled to an external drive motor, a calibrated HPLC delivery system, a heated probe tip and means located adjacent the probe tip for direct ionization of the residue on the belt. The interface is also capable of being readily adapted to fit any mass spectrometer.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: Sepragen Corporation (San Leandro, CA)
• Patent Number(s): US 4867947
• OSTI ID: 867111
• Country of Publication: United States
• Language: English

Related Subjects

interface
liquid
chromatograph-mass
spectrometer
moving
belt
real-time
high-performance
chromatograph
hplc
mass
analysis
strips
solvent
emerges
column
leaves
residue
suitable
mass-spectral
portable
stand-alone
apparatus
plural
stage
vacuum
station
continuous
ribbon
drive
train
magnetically
coupled
external
motor
calibrated
delivery
heated
probe
tip
means
located
adjacent
direct
ionization
capable
readily
adapted
fit
performance liquid
liquid chromatograph
chromatograph-mass spectrometer
spectral analysis
probe tip
mass spectrometer
located adjacent
magnetically coupled
drive motor
drive train
means located
hplc column
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