Tin-117m-labeled stannic (Sn.sup.4+) chelates

Patent · Mon Dec 31 23:00:00 EST 1984

OSTI ID:865544

Srivastava, Suresh C ^[1]; Meinken, George E ^[2]; Richards, Powell ^[3]

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1. Setauket, NY
2. Middle Island, NY
3. Bayport, NY

The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.

• Research Organization: ASSOC UNIVERSITIES INC
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4533541
• OSTI ID: 865544
• Country of Publication: United States
• Language: English

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