Tin-117m-labeled stannic (Sn/sup 4 +/) chelate of diethylenetriamine pentaacetic acid (DTPA) for application in diagnosis and therapy
The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- Dept. of Energy
- Patent Number(s):
- None
- Application Number:
- ON: DE84011272
- OSTI ID:
- 6965212
- Country of Publication:
- United States
- Language:
- English
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Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use
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Related Subjects
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BONE SEEKERS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL PREPARATION
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
DTPA
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RADIOPROTECTIVE SUBSTANCES
RODENTS
STABLE ISOTOPES
SYNTHESIS
TIN 117
TIN ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES