Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use
- Setauket, NY
- Middle Island, NY
Radiopharmaceutical compositions including .sup.117m Sn labeled stannic (Sn.sup.4+) chelates are provided. The chelates are preferably polyhydroxycarboxylate, such as oxalates, tartrates, citrates, malonates, gluconates, glucoheptonates and the like. Methods of making .sup.117m Sn-labeled (Sn.sup.4+) polyhydroxycarboxylic chelates are also provided. The foregoing pharmaceutical compositions can be used in methods of preparing bone for scintigraphical analysis, for radiopharmaceutical skeletal imaging, treatment of pain resulting from metastatic bone involvement, treatment of primary bone cancer, treatment of cancer resulting from metastatic spread to bone from other primary cancers, treatment of pain resulting from rheumatoid arthritis, treatment of bone/joint disorders and to monitor radioactively the skeletal system.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY
- DOE Contract Number:
- AC02-98CH10886
- Assignee:
- Brookhaven Science Associates (Upton, NY)
- Patent Number(s):
- US 6231832
- OSTI ID:
- 873731
- Country of Publication:
- United States
- Language:
- English
The development and in-vivo behavior of tin containing radiopharmaceuticals—I. Chemistry, preparation, and biodistribution in small animals
|
journal | January 1985 |
The development and in-vivo behavior of tin containing radiopharmaceuticals—II. Autoradiographic and scintigraphic studies in normal animals and in animal models of bone disease
|
journal | January 1985 |
Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
|
journal | January 1993 |
Tin-117m: Production, chemistry and evaluation as a bone-scanning agent
|
journal | June 1973 |
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