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Assay for mutagenesis in heterozygous diploid human lymphoblasts

Patent ·
OSTI ID:864055
 [1];  [2];  [3];  [3]
  1. Somerville, MA
  2. Brookline, MA
  3. Cambridge, MA
+ Show Author Affiliations
An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cytidine deaminase. Since human lymphoblastoid cells contain two genes for these enzymes, heterozygotes of human lymphoblastoid cells are used in this assay.
DOE Contract Number:
EE-77-S-02-4267
Assignee:
Massachusetts Institute of Technology (Cambridge, MA)
Patent Number(s):
US 4302535
OSTI ID:
864055
Country of Publication:
United States
Language:
English

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Assay for mutagenesis in heterozygous diploid human lymphoblasts
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Related Subjects

/435/
administration
assay
caused
cell
cell line
cell lines
cells
cells contain
contain
cytidine
damage
damage caused
deaminase
determining
diploid
diploid human
disclosed
employed
enzymes
genes
heterozygotes
heterozygous
human
kinase
lines
locus
lymphoblastoid
lymphoblasts
mutagen
mutagenesis
mutagenic
suspected
thymidine
uridine