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Assay for mutagenesis in heterozygous diploid human lymphoblasts

Patent ·
OSTI ID:7000016
; ; ; ;
An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cytidine deaminase. Since human lymphoblastoid cells contain two genes for these enzymes, heterozygotes of human lymphoblastoid cells are used in this assay. 7 figs.
Assignee:
Massachusetts Inst. of Tech., Cambridge, MA (United States)
Patent Number(s):
US 4302535; A
Application Number:
PPN: US 6-079549
OSTI ID:
7000016
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIPLOIDY
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTAGEN SCREENING
MUTAGENESIS
MUTAGENS
PLOIDY
SCREENING
SOMATIC CELLS