Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
A thymidine kinase heterozygote designated H2BT has been isolated from the human lymphoblast line HH4. Significant increase in the trifluorothymidine-resistant fraction was observed in the new cell line following treatment with the mutagens ICR-191 and butylmethansulfonate. Phenotypic expression was complete forty-eight hours after treatment.
- Research Organization:
- Massachusetts Inst. of Tech., Cambridge
- OSTI ID:
- 6197104
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 84:2; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301 -- Cytology-- Tracer Techniques
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ENZYMES
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTAGEN SCREENING
MUTANTS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTYPE
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PYRIMIDINES
RIBOSIDES
SCREENING
SOMATIC CELLS
SULFONATES
THYMIDINE
TRANSFERASES
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ENZYMES
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTAGEN SCREENING
MUTANTS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTYPE
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PYRIMIDINES
RIBOSIDES
SCREENING
SOMATIC CELLS
SULFONATES
THYMIDINE
TRANSFERASES