Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes

Patent · Thu Nov 10 00:00:00 EST 1977

OSTI ID:862792

Rahman, Yueh Erh ^[1]

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1. Downers Grove, IL

A method is provided for transferring a polyaminopolycarboxylic acid chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes, which liposomes will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. The chelating agent is encapsulated within liposomes by drying a lipid mixture to form a thin film and wetting the lipid film with a solution containing the chelating agent. Mixing then results in the formation of a suspension of liposomes encapsulating the chelating agent, which liposomes can then be separated.

• Research Organization: UNITED STATES ATOMIC ENERGY COMMISSION
• Assignee: United States of America as represented by United States Energy (Washington, DC)
• Patent Number(s): US 4016290
• Application Number: 05/630,474
• OSTI ID: 862792
• Country of Publication: United States
• Language: English

Related Subjects

method
encapsulating
polyaminopolycarboxylic
acid
chelating
agents
liposomes
provided
transferring
agent
cellular
membrane
charged
cells
encapsulated
drying
lipid
mixture
form
film
wetting
solution
containing
mixing
results
formation
suspension
separated
cellular membrane
solution containing
chelating agents
chelating agent
carboxylic acid
charged chelating
aminopolycarboxylic acid
polyaminopolycarboxylic acid
acid chelating
/514/264/428/