Liposome encapsulation of chelating agents

Patent · Tue Jan 13 00:00:00 EST 1976

OSTI ID:5088442

Rahman, Y E

A method for transferring a chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes and carrying the liposome-encapsulated chelating agent to the cellular membrane where the liposomes containing the chelating agent will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. A chelating agent can be introduced into the interior of a cell of a living organism wherein the liposomes will be decomposed, releasing the chelating agent to the interior of the cell. The released chelating agent will complex intracellularly deposited toxic heavy metals, permitting the more soluble metal complex to transfer across the cellular membrane from the cell and subsequently be removed from the living organism.

• Assignee: Energy Research and Development Administration
• Patent Number(s): US 3932657
• OSTI ID: 5088442
• Resource Relation: Patent File Date: Filed date 12 Nov 1973; Other Information: PAT-APPL-415,077
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CHELATING AGENTS
MEMBRANE TRANSPORT
METALS
CHELATES
ANIMAL CELLS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
CELL MEMBRANES
CLEARANCE
METABOLISM
THERAPY
TOXIC MATERIALS
CELL CONSTITUENTS
COMPLEXES
ELEMENTS
KINETICS
MEMBRANES
REACTION KINETICS
550600* - Medicine
550500 - Metabolism