Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes

Patent · Tue Apr 05 00:00:00 EST 1977

OSTI ID:7277185

Rahman, Y E

A method is provided for transferring a polyaminopolycarboxylic acid chelating agent across a cellullar membrane by encapsulating the charged chelating agent within liposomes, which liposomes will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. The chelating agent is encapsulated within liposomes by drying a lipid mixture to form a thin film and wetting the lipid film with a solution containing the chelating agent. Mixing then results in the formation of a suspension of liposomes encapsulating the chelating agent, which liposomes can then be separated.

• Assignee: Energy Research and Development Administration
• Patent Number(s): US 4016290
• OSTI ID: 7277185
• Resource Relation: Patent File Date: Filed date 10 Nov 1975; Other Information: PAT-APPL-630,474
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHELATING AGENTS
MEMBRANE TRANSPORT
SEPARATION PROCESSES
AMINO ACIDS
CARBOXYLIC ACIDS
CELL MEMBRANES
LIPIDS
CELL CONSTITUENTS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
550200* - Biochemistry