Liposome encapsulation of chelating agents

Patent · Tue Jan 13 00:00:00 EST 1976

OSTI ID:862445

Rahman, Yueh Erh ^[1]

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1. Downers Grove, IL

A method for transferring a chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes and carrying the liposome-encapsulated chelating agent to the cellular membrane where the liposomes containing the chelating agent will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. A chelating agent can be introduced into the interior of a cell of a living organism wherein the liposomes will be decomposed, releasing the chelating agent to the interior of the cell. The released chelating agent will complex intracellularly deposited toxic heavy metals, permitting the more soluble metal complex to transfer across the cellular membrane from the cell and subsequently be removed from the living organism.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• DOE Contract Number: W-31109-ENG-38
• Assignee: United States of America as represented by United States Energy (Washington, DC)
• Patent Number(s): US 3932657
• Application Number: 05/415,077
• OSTI ID: 862445
• Country of Publication: United States
• Language: English

Related Subjects

liposome
encapsulation
chelating
agents
method
transferring
agent
cellular
membrane
encapsulating
charged
liposomes
carrying
liposome-encapsulated
containing
cells
introduced
interior
cell
living
organism
decomposed
releasing
released
complex
intracellularly
deposited
toxic
heavy
metals
permitting
soluble
metal
transfer
subsequently
removed
cellular membrane
heavy metal
chelating agents
chelating agent
heavy metals
soluble metal
metal complex
charged chelating
liposomes containing
liposome encapsulation
/514/