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Incidence of radiation-induced cataract in single and parabiotic rats

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574379· OSTI ID:7364206
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Grossly visible cataract developed by 500 days postradiation in 74 percent of the irradiated members of parabiotic pairs of NEDH rats, one of which had received 1000 R whole-body 250 kVp x radiation while the other was shielded to assure survival of the pair. The earliest time at which induced cataract was noted was 106 days postradiation, with the peak rate of occurrence between 300 and 400 days. Other ocular components than the lens, notably the iris and ciliary body, also showed radiation effects. The incidence of cataract in the shielded partners was 0.2 percent, the same as in control parabiont pairs. No spontaneous cataracts were found in single control rats. There was no abscopal effect on the eyes of the shielded partners. Conversely, presence of the shielded partner offered no protection to the irradiated eyes. A few single rats survived a whole-body dose of 1000 R. Three hundred days after radiation 3 percent of such rats developed cataract. By 600 days 82 percent of the survivors had developed cataract. As the dose was increased in several experiments from 700 to 1100 R, the incidence of cataract in survivors also increased from 31 percent to 90 percent. (auth)
Research Organization:
New England Deaconess Hospital, Boston
OSTI ID:
7364206
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 65:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CATARACTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
EYES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MOSAICISM
ORGANS
PARABIOSIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION