Leukemia and lymphoma in irradiated parabiont rats. [X radiation]
Leukemia and lymphoid tumors each have a 2 percent spontaneous rate in NEDH rats. Rats are less prone to such tumors than mice. Parabiosis of syngeneic rats permits one partner to survive a whole-body x-ray exposure of 1000 R if the other partner is shielded. Parabiosis alone induced a slight increase in the rates of incidence of both leukemia and solid lymphoid tumors, to about 5 percent. Exposure of one parabiont partner to 1000 R did not increase the incidence rates of these tumors significantly in either partner and sharply decreased the incidence rate of lymphosarcoma in female pairs. Monocytoid and myeloid leukemias were the more common types. Leukemia was often but not always shared by both partners of a pair. The solid lymphoid tumors tended to respond similarly following parabiosis and radiation. These tumors were usually restricted to one partner. Their incidence rates did not differ significantly between the irradiated and shielded partners, for lymphosarcoma 0.3 percent in the irradiated and 1.0 percent in the shielded and for reticulum cell sarcoma 1.1 and 1.5 percent, respectively.
- Research Organization:
- Cancer Research Inst., Boston
- OSTI ID:
- 7090326
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 72:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
IONIZING RADIATIONS
LEUKEMIA
LYMPHOMAS
MAMMALS
MOSAICISM
NEOPLASMS
PARABIOSIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
VERTEBRATES
X RADIATION