Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Radiation carcinogenesis. Progress report IV, 15 March 1976--15 May 1977. [Abscopal effects of radiation on parabiant rats]

Technical Report ·
DOI:https://doi.org/10.2172/7098002· OSTI ID:7098002
;

The series of parabiont and irradiated rats has been completed, the lesions diagnosed and the data pertinent to tumors computerized and partly analyzed. The same series yielded 74 percent incidence of cataract in the irradiated partner following a whole-body dose of 1000 R with 0.2 percent in the shielded partner and also in controls. There was no abscopal effect. Other structures of the eye beside the lens, particularly the retina, showed extensive radiation damage. Parabiosis increased the incidence rate of leukemia from one percent in control single rats to five percent. Irradiation of one partner decreased the rate to 2.5 percent. Similar effects were noted for solid lymphoid tumors. A pilot study of prostatic cancer in irradiated parabiont rats demonstrated a tenfold increase in incidence. Experimental protocols bearing on cocarcinogenesis have been initiated in mice and rats, using radiation, asbestos and chemical carcinogens, but no results have been as yet obtained. We have obtained additional evidence suggesting the importance of prolactin as a cocarcinogen with radiation for induction of mammary tumors in the rat and are continuing our collaborative study of hormonal aasays in the blood of parabiont rats.

Research Organization:
New England Deaconess Hospital, Boston, MA (USA). Cancer Research Inst.
OSTI ID:
7098002
Report Number(s):
COO-3017-31
Country of Publication:
United States
Language:
English

Similar Records

Radiation carcinogenesis. Progress report V, 16 May 1977--15 May 1978
Technical Report · Sat Dec 31 23:00:00 EST 1977 · OSTI ID:6538975
Mammary and other tumors as a response to radiation and multiple stresses
Journal Article · Mon May 01 00:00:00 EDT 1978 · Arch. Pathol. Lab. Med.; (United States) · OSTI ID:6660773
Leukemia and lymphoma in irradiated parabiont rats. [X radiation]
Journal Article · Wed Nov 30 23:00:00 EST 1977 · Radiat. Res.; (United States) · OSTI ID:7090326

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCOPAL RADIATION EFFECTS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CARCINOGENS
CATARACTS
DISEASES
EYES
GLANDS
GONADOTROPINS
HEMIC DISEASES
HORMONES
LEUKEMIA
LTH
MAMMALS
MAMMARY GLANDS
MOSAICISM
NEOPLASMS
ORGANS
PARABIOSIS
PATHOGENESIS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES