Mammary and other tumors as a response to radiation and multiple stresses

Journal Article · Mon May 01 04:00:00 EDT 1978 · Arch. Pathol. Lab. Med.; (United States)

OSTI ID:6660773

Warren, S; Brown, C E

Parabiosis of paired NEDH rats and subsequent irradiation of one produced multiple stresses, particularly altered hormonal milieu. Benign mammary tumors developed in 8.6% of the control pairs, 12.7% of the shielded partners, and 19.7% of the irradiated rats. Mammary cancers developed in 5% of control pairs, 14.2% of the shielded partners, and 11.9% of the irradiated rats. With increased amounts of prolactin, the rate was 50% in shielded partners, 10% in the irradiated rats. Mesenchymal sarcomas develop at the anastomosis in parabiont rats. Their incidence rate in single controls is 3.1%, in parabiont control pairs 12.5%, in pairs with one partner irradiated 16.6%, and with both irradiated 23.1%. The incidence rate in other parts was increased threefold over controls in the irradiated partners. Radiation appears to be the dominant factor in both mammary and anastomotic tumors.

• Research Organization: Cancer Research Inst., Boston
• OSTI ID: 6660773
• Journal Information: Arch. Pathol. Lab. Med.; (United States), Journal Name: Arch. Pathol. Lab. Med.; (United States) Vol. 102:5; ISSN APLMA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL STRESS
BODY
DISEASES
ETIOLOGY
EXPERIMENTAL NEOPLASMS
GLANDS
HORMONES
IRRADIATION
MAMMALS
MAMMARY GLANDS
MOSAICISM
NEOPLASMS
ORGANS
PARABIOSIS
RADIATION EFFECTS
RATS
RODENTS
SARCOMAS
VERTEBRATES