Carcinoma of the prostate in irradiated parabiotic rats

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Cancer Res.; (United States)

OSTI ID:6754729

Brown, C E; Warren, S

Twelve hundred fifty-two pairs of male NEDH rats were parabiosed, one partner received a single dose of 1000 R x-radiation, and the other rat was shielded with lead. Eleven hundred twenty pairs survived over 200 days and constitute the basis of this report. Twenty-five of the irradiated partners developed malignant tumors of the prostate, 19 of which were adenocarcinomas. One adenocarcinoma appeared in the shielded partners and one in a control group of 586 parabiosed and single rats. The long-term effect of a single dose of 1000 R whole-body x-radiation is weakly carcinogenic for the rat prostate.

• Research Organization: Cancer Research Inst., Boston
• OSTI ID: 6754729
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 38:1; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOMAS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
GLANDS
IONIZING RADIATIONS
LEAD
MALE GENITALS
MAMMALS
METALS
MOSAICISM
NEOPLASMS
ORGANS
PARABIOSIS
PROSTATE
RADIATION PROTECTION
RADIATIONS
RATS
RODENTS
SHIELDS
SURVIVAL TIME
VERTEBRATES
X RADIATION