Increased carcinogenicity of 2,6-dimethylnitrosomorpholine compared with nitrosomorpholine in rats

Journal Article · Fri Aug 01 04:00:00 EDT 1975 · Cancer Res.; (United States)

OSTI ID:7358691

Lijinsky, W; Taylor, H W

Nitrosomorpholine was given to rats in drinking water at the rate of 4 mg/week for 30 weeks. Tumors of the liver were induced in 53% of treated animals and were of both hepatocellular and Kupffer cell origin. One-half of the treated animals were alive 75 weeks after the beginning of treatment, but only 2 survived to 104 weeks. 2,6-Dimethylnitrosomorpholine was given to rats at the same molar concentration in drinking water for 30 weeks (5 mg/week). All of these animals died with tumors within 34 weeks after the beginning of treatment; these tumors were mainly in the esophagus and nasal turbinates, and only 1 liver tumor was seen. This greatly changed tumorigenicity of the dimethyl compound might be due to steric factors or to enhanced reactivity at the positions ..cap alpha.. to the nitroso function induced by the methyl groups at the ..beta.. position. (auth)

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7358691
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 35; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
CARCINOGENESIS
CARCINOGENS
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
ESOPHAGUS
GLANDS
HEPATOMAS
HYDROGEN COMPOUNDS
INDUCTION
LIVER
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PHARYNX
RATS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
WATER