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Carcinogenicity of N-nitroso-3,4-dichloro- and N-nitroso-3,4-dibromopiperidine in rats

Journal Article · · Cancer Res.; (United States)
OSTI ID:7358690
;

The carcinogenic potencies of 3,4-dichloro- and 3,4-dibromonitrosopiperidine were compared with that of nitrosopiperidine by feeding to groups of 15 male rats in drinking water. A treatment of 15 weeks with a total of 0.5 mmole of the dichloro compound led to death of all animals before 24 weeks with tumors of the tongue, pharynx, esophagus, nonglandular stomach, nasal turbinates, trachea, bronchi, and bronchioles. Treatment of 27 weeks with the dibromo compound, a total of 1.0 mmole, caused death of all the animals by 41 weeks, with the same types of tumors. One-half of the rats treated with an almost 3-fold higher daily dose of nitrosopiperidine, 3.9 mmoles total, were alive at 40 weeks, and all were not dead until 55 weeks. Most of these animals died with tumors of the tongue, pharynx, esophagus, and nonglandular stomach and with squamous cell tumors and olfactory carcinomas of the nasal cavity, but there were no tumors of the respiratory tree. Substitution of chlorine or bromine in nitrosopiperidine greatly increased the carcinogenicity of the compound. (auth)

Research Organization:
Oak Ridge National Lab., TN
OSTI ID:
7358690
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 35; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AZINES
BODY
BODY AREAS
BROMINE
BRONCHI
CARCINOGENESIS
CARCINOGENS
CHLORINE
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
ELEMENTS
ESOPHAGUS
FACE
GASTROINTESTINAL TRACT
HALOGENS
HEAD
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
NONMETALS
NOSE
ORAL ADMINISTRATION
ORAL CAVITY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PHARYNX
PIPERIDINES
PYRIDINES
RATS
RESPIRATORY SYSTEM
RODENTS
STOMACH
TONGUE
TRACHEA
VERTEBRATES
WATER