Effect of substituents on the carcinogenicity of N-nitrosopyrrolidine in Sprague--Dawley rats

Journal Article · Tue Jun 01 00:00:00 EDT 1976 · Cancer Res.; (United States)

OSTI ID:7306641

Lijinsky, W; Taylor, H W

N-Nitrosopyrrolidine and two of its derivatives were prepared and fed in drinking water to Sprague-Dawley rats to compare the effects of substituents on the carcinogenicity of the N-nitrosopyrrolidine molecule. 3,4-Dichloro-N-nitrosopyrrolidine induced esophageal tumors in 13 of 14 animals, olfactory carcinomas in 4, and a hepatocellular tumor in 1. All animals that received this compound were dead at 55 weeks after the start of the experiment. N-Nitrosopyrrolidine induced hepatocellular tumors in 26 of 29 animals and induced 1 olfactory carcinoma. Not all animals in this group were dead until 104 weeks of the experiment. 2,5-Dimethyl-N-nitrosopyrrolidine induced only 2 hepatocellular tumors in 29 animals. The ..cap alpha..-methyl substitution diminished the liver carcinogenicity, while the ..beta.. chlorine substitution affected a different target organ, the esophagus, and greatly reduced the time to death with tumors.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7306641
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 36; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
ESOPHAGUS
GLANDS
HETEROCYCLIC COMPOUNDS
LIVER
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PYRROLES
PYRROLIDINES
RATS
RODENTS
VERTEBRATES