Carcinogenicity test of two unsaturated derivatives of N-nitrosopiperidine in Sprague--Dawley rats

Journal Article · Wed Dec 01 04:00:00 EST 1976 · Ann. Surg.; (United States)

OSTI ID:7212788

Lijinsky, W; Taylor, H W

Two unsaturated derivatives of N-nitrosopiperidine (NP), N-nitroso-1,2,3,6-tetrahydropyridine (NTP) and N-nitrosoguvacoline (NGC), were administered to Sprague-Dawley rats as solutions in drinking water at concentrations equimolar (0.88 x 10/sup -3/M) with those used to test NP. NTP gave rise to hepatocellular tumors in contrast to the esophageal or olfactory tumors that were induced by NP. NGC did not induce tumors under these test conditions.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7212788
• Journal Information: Ann. Surg.; (United States), Journal Name: Ann. Surg.; (United States) Vol. 57:6; ISSN ANSUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZINES
BODY
BRAIN
CARCINOGENESIS
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISEASES
ESOPHAGUS
GLANDS
HETEROCYCLIC COMPOUNDS
LIVER
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NITROSO COMPOUNDS
OLFACTORY BULBS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PIPERIDINES
PYRIDINES
RATS
RODENTS
VERTEBRATES