Tumorigenesis by oxygenated nitrosopiperidines in rats

Journal Article · Mon Sep 01 04:00:00 EDT 1975 · J. Natl. Cancer Inst.; (United States)

OSTI ID:7299563

Lijinsky, W; Taylor, H W

Three oxygenated N-nitrosopiperidines--nitroso-3-piperidinol, nitroso-4-piperidinol, and nitroso-4-piperidone--were prepared and given in drinking water at equivalent molar doses to Sprague-Dawley rats. All were potent carcinogens; 100 percent of the rats developed tumors in all treatment groups. Nitroso-3-piperidinol resembled nitrosopiperidine in inducing a high incidence of tumors of the nasal cavity and upper alimentary tract, and a few liver tumors. Nitroso-4-piperidinol and nitroso-4-piperidone caused a high incidence of tumors of the nasal cavity but very few tumors of the upper alimentary tract. After treatment with the 4-substituted compounds, a high incidence of liver tumors was observed in females but not in males. (auth)

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7299563
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 55:3; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AZINES
BODY
BODY AREAS
CARCINOGENESIS
CARCINOGENS
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
ESOPHAGUS
FACE
GLANDS
HEAD
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LIVER
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
NOSE
ORAL CAVITY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PHARYNX
PIPERIDINES
PYRIDINES
RATS
RESPIRATORY SYSTEM
RODENTS
TONGUE
VERTEBRATES
WATER