Carcinogenicity of methylated derivatives of N-nitrosodiethylamine and related compounds in Sprague--Dawley rats

Journal Article · Wed Jan 31 23:00:00 EST 1979 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6421186

Lijinsky, W; Taylor, H W

Five nitrosamines, which can be considered alkyl derivatives of N-nitrosodiethylamine, were tested for carcinogenicity by administration to Sprague--Dawley rats in drinking water at approximately equimolar concentrations. N-Nitrosodi-n-propylamine was a potent carcinogen but less so than N-nitrosodiethylamine and gave the same spectrum of tumors. N-Nitrosodiisopropylamine was very much weaker than N-nitrosodiethylamine and induced only tumors of the nasal turbinates in significant incidence. At the doses given, neither N-nitrosodiisobutylamine nor N-nitrosodi-sec-butylamine was significantly carcinogenic. In contrast, the cyclic nitrosamine N-nitrosohexamethyleneimine was equally potent with N-nitrosodiethylamine and gave the same spectrum of tumors in liver, esophagus, and nasal turbinates. The results support the concept that oxidation at the alpha carbon atom of nitrosamines is a significant step in carcinogenesis.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 6421186
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 62:2; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
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59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
AMINES
ANIMALS
AQUEOUS SOLUTIONS
BODY
CARCINOGENESIS
CHRONIC INTAKE
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
ESOPHAGUS
GLANDS
INGESTION
INTAKE
LIVER
MAMMALS
MIXTURES
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
SENSE ORGANS
SOLUTIONS
VERTEBRATES