Carcinogenicity of N'-Nitrosonornicotine in Sprague--Dawley rats
Journal Article
·
· Ann. Surg.; (United States)
OSTI ID:7256404
N'-Nitrosonornicotine was added to the drinking water of outbred Sprague-Dawley rats. Adenocarcinomas of the olfactory epithelium occurred in all 15 rats, squamous papillomas of the esophagus in 1, squamous papillomas of the nonglandular stomach in 1, and a hepatocellular tumor in 1. The possible ingestion and subsequent in vivo nitrosation of nicotine and/or nornicotine could create a serious carcinogenic hazard to cigarette smokers.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 7256404
- Journal Information:
- Ann. Surg.; (United States), Journal Name: Ann. Surg.; (United States) Vol. 57:6; ISSN ANSUA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
AMINES
ANIMALS
AZINES
AZOLES
BODY
BRAIN
CARCINOGENESIS
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DISEASES
DRINKING WATER
EPITHELIUM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NICOTINE
NITROSO COMPOUNDS
OLFACTORY BULBS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PYRIDINES
PYRROLES
PYRROLIDINES
RATS
RODENTS
TISSUES
VERTEBRATES
WATER
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
AMINES
ANIMALS
AZINES
AZOLES
BODY
BRAIN
CARCINOGENESIS
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DISEASES
DRINKING WATER
EPITHELIUM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NICOTINE
NITROSO COMPOUNDS
OLFACTORY BULBS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PYRIDINES
PYRROLES
PYRROLIDINES
RATS
RODENTS
TISSUES
VERTEBRATES
WATER