Reduction of rat liver carcinogenicity of 4-Nitrosomorpholine by. cap alpha. -deuterium substitution

Journal Article · Wed Dec 01 04:00:00 EST 1976 · Ann. Surg.; (United States)

OSTI ID:7256403

Lijinsky, W ^[1]; Taylor, H W; Keefer, L K

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1. Oak Ridge National Lab., TN

Groups of 30 male Sprague-Dawley rats were given 4-nitrosomorpholine-3,3,5,5-d/sub 4/ in their drinking water at concentrations of 0.35 and 0.07 x 10/sup -3/ M for 30 weeks. Two similar groups of rats were simultaneously given unlabeled 4-nitrosomorpholine (NM) at the same molar concentrations; all animals were observed throughout their lives. Those receiving the ..cap alpha..-deuterium-labeled compound had significantly fewer liver tumors than did the corresponding animals receiving the unlabeled compound. The difference in potency appeared to be at least fivefold, a magnitude consistent with a primary kinetic isotope effect on the carcinogenic action of NM. Thus breakage of a bond linking a hydrogen (deuterium) atom with a carbon adjacent to the nitrosamino function may be involved in a rate-limiting step of carcinogenesis by NM.

• OSTI ID: 7256403
• Journal Information: Ann. Surg.; (United States), Journal Name: Ann. Surg.; (United States) Vol. 57:6; ISSN ANSUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
DEUTERIUM
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
ETHERS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPES
LABELLING
LIGHT NUCLEI
LIVER
MAMMALS
MORPHOLINES
NEOPLASMS
NITROSO COMPOUNDS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
RATS
RODENTS
STABLE ISOTOPES
VERTEBRATES
WATER