Intramuscular immunization of mice with irradiated Plasmodium berghei sporozoites. Enhancement of protection with albumin

Journal Article · Sat Nov 01 04:00:00 EST 1975 · Am. J. Trop. Med. Hyg.; (United States)

OSTI ID:7356532

Kramer, L D; Vanderberg, J P

These studies have confirmed a previous report which demonstrated that intramuscularly injected irradiated sporozoites of Plasmodium berghei are far less effective than those injected intravenously in protectively immunizing mice against sporozoite-induced malaria. Because albumin has been shown to induce motility in Plasmodium sporozoites, attempts were made to determine whether the use of albumin in immunizing inocula given intramuscularly might enhance the protection thus obtained. The results showed that albumin did indeed significantly enhance the development of protective immunity, though this protection was still considerably less than that obtained by intravenous immunization. This effect of albumin may be due to its ability to induce motility in the injected sporozoites, thereby permitting them to reach and enter blood vessels more readily.

• Research Organization: New York Univ., NY
• OSTI ID: 7356532
• Journal Information: Am. J. Trop. Med. Hyg.; (United States), Journal Name: Am. J. Trop. Med. Hyg.; (United States) Vol. 24:6; ISSN AJTHA
• Country of Publication: United States
• Language: English

Related Subjects

560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
560154 -- Radiation Effects on Animals-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMIC DISEASES
IMMUNITY
INACTIVATION
INFECTIOUS DISEASES
INVERTEBRATES
IONIZING RADIATIONS
IRRADIATION
MALARIA
MAMMALS
MICE
MICROORGANISMS
PARASITES
PLASMODIUM
PROTOZOA
RADIATION EFFECTS
RADIATIONS
RODENTS
SPORES
VACCINES
VERTEBRATES