T lymphocytes from mice immunized with irradiated sporozoites eliminated malaria from hepatocytes

Technical Report · Mon Jan 01 04:00:00 EST 1990

OSTI ID:5449116

Hoffman, S L; Isenbarger, D; Long, G W; Sedegah, M; Szarfman, A

When mice are immunized with radiation-attenuated sporozoites they are solidly protected against sporozoite challenge by an immune response that has been shown to require CD8+ lymphocytes in several strains of mice. The target of this CD8+ T-cell-dependent immunity has not been established. Immune BALB/c mice were shown to develop malaria-specific. CD8+ T-cell-dependent inflammatory infiltrates in their livers after challenge with Plasmodium berghei sporozoites. Spleen cells from immune BALB/c and C57BL/6 mice eliminated hepatocytes infected with the liver stage of P. berghei in vitro. The activity against infected hepatocytes is not inhibited by antibodies to interferon-y and is not present in culture supernatants. It is generally restricted, an indication that malaria antigens on the hepatocyte surface are recognized by immune T-effector cells.

• Research Organization: Naval Medical Research Inst., Bethesda, MD (United States)
• OSTI ID: 5449116
• Report Number(s): AD-A-235908/1/XAB; NMRI--90-144
• Country of Publication: United States
• Language: English

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553003* -- Agriculture & Food Technology-- Pest & Disease Control-- (1987-)
60 APPLIED LIFE SCIENCES
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
IMMUNITY
INFECTIOUS DISEASES
INVERTEBRATES
IRRADIATION
LEUKOCYTES
LIVER CELLS
LYMPHOCYTES
MALARIA
MAMMALS
MATERIALS
MICE
MICROORGANISMS
PARASITES
PARASITIC DISEASES
PLASMODIUM
PROTOZOA
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SPOROZOA
VACCINES
VERTEBRATES