Immunity to sporozoite-induced malaria infection in mice. I. The effect of immunization of T and B cell-deficient mice. [X Radiation]

Journal Article · Fri Apr 01 04:00:00 EST 1977 · J. Immunol.; (United States)

OSTI ID:7259821

Chen, D H; Tigelaar, R E; Weinbaum, F I

The cellular basis of immunity to sporozoites was investigated by examining the effect of immunization of T and B cell-deficient C57BL/6N x BALB/c AnN F/sub 1/ (BLCF/sub 1/) mice compared to immunocompetent controls. Immunization of T cell-deficient (ATX-BM-ATS) BLCF/sub 1/ mice with x-irradiated sporozoites did not result in the generation of protective immunity. The same immunization protocols protected all immunocompetent controls. In contrast, B cell-deficient (..mu..-suppressed) BLCF/sub 1/ mice were protected by immunization in the majority of cases. The absence of detectable serum circumsporozoite precipitins or sporozoite neutralizing activity in the ..mu..-suppressed mice that resisted a sporozoite challenge suggests a minor role for these humoral factors in protection. These data demonstrate a preeminent role for T cells in the induction of protective immunity in BLCF/sub 1/ mice against a P. berghei sporozoite infection.

• Research Organization: Lab. of Parasitic Diseases, Bethesda, MD
• OSTI ID: 7259821
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 118:4; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
IMMUNITY
INFECTIOUS DISEASES
INFECTIVITY
INVERTEBRATES
IONIZING RADIATIONS
MALARIA
MAMMALS
MICE
MICROORGANISMS
PARASITES
PLASMODIUM
PROTOZOA
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
THYMOCYTES
VERTEBRATES
X RADIATION