Rodent malaria: BCG-induced protection and immunosuppression. [Mice, gamma radiation, Plasmodium berghei]

Journal Article · Sun Oct 01 04:00:00 EDT 1978 · J. Clin. Endocrinol. Metab.; (United States)

OSTI ID:6539996

Smrkovski, L L; Strickland, G T

One dose of 10/sup 7/ viable units of Mycobacterium bovis, strain BCG, protected a significant number of Swiss mice from a primary challenge with 10/sup 4/ thoracic sporozoites of Plasmodium berghei. Immunization with irradiated sporozoites induced greater protection than that observed in BCG-treated animals. Mice treated with BCG and surviving a primary sporozoite challenge were not protected from rechallenge, whereas mice immunized with irradiated sporozoites and surviving initial challenge of sporozoites were solidly immune to further challenge. Immunizing mice with BCG and irradiated sporozoites simulataneously resulted in a synergistic effect of increased protection against a primary challenge of sporozoites only if the two immunogens were administered on the same day and if the mice were challenged 1 to 3 days later. Mice given BCG and irradiated sporozoites and surviving a primary challenge of sporozoites were unable to survive rechallenge. BCG given to mice previously immunized with irradiated sporozoites suppressed their protective immunity against sporozoite challenge.

• Research Organization: Naval Medical Research Inst., Bethesda, MD
• OSTI ID: 6539996
• Journal Information: J. Clin. Endocrinol. Metab.; (United States), Journal Name: J. Clin. Endocrinol. Metab.; (United States) Vol. 47:4; ISSN JCEMA
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMIC DISEASES
IMMUNE REACTIONS
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
IONIZING RADIATIONS
MALARIA
MAMMALS
MICE
MICROORGANISMS
MYCOBACTERIUM
RADIATION EFFECTS
RADIATIONS
RODENTS
VACCINES
VERTEBRATES