Effect of 60Co-irradiation on the development and immunogenicity of Plasmodium berghei sporozoites in Anopheles stephensi mosquitoes
Journal Article
·
· J. Parasitol.; (United States)
OSTI ID:7004869
Protection conferred to mice by Plasmodium berghei sporozoites increased significantly when the time interval between 60Co-irradiation of the infected mosquitoes and harvest of sporozoites increased. One thousand sporozoites conferred no protection against challenge if harvested on the day of irradiation, but protected 60% of recipient mice when harvested 28 days postirradiation. When the time between feeding of mosquitoes and irradiation was varied, sporozoites from mosquitoes irradiated 3 days after feeding were infective for mice. Sporozoites from mosquitoes irradiated on day 10 postfeeding were not infective, but were immunogenic. In all experiments a decline occurred in the number of recoverable sporozoites over a 28-day period postirradiation to less than 10% of the yield on the day of irradiation.
- Research Organization:
- Immunoparasitology Branch, Naval Medical Research Institute, Bethesda, Maryland
- OSTI ID:
- 7004869
- Journal Information:
- J. Parasitol.; (United States), Journal Name: J. Parasitol.; (United States) Vol. 69:5; ISSN JOPAA
- Country of Publication:
- United States
- Language:
- English
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Technical Report
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OSTI ID:6483490
Related Subjects
560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DIPTERA
DISEASES
INFECTIOUS DISEASES
INFECTIVITY
INSECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MALARIA
MAMMALS
MICE
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
MOSQUITOES
NUCLEI
ODD-ODD NUCLEI
PARASITES
PARASITIC DISEASES
PLASMODIUM
PROTOZOA
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
SPOROZOA
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DIPTERA
DISEASES
INFECTIOUS DISEASES
INFECTIVITY
INSECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MALARIA
MAMMALS
MICE
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
MOSQUITOES
NUCLEI
ODD-ODD NUCLEI
PARASITES
PARASITIC DISEASES
PLASMODIUM
PROTOZOA
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
SPOROZOA
VERTEBRATES
YEARS LIVING RADIOISOTOPES