Humoral antibody response in mice after single dose exposure to lead or cadmium

Journal Article · Sun Feb 01 04:00:00 EST 1976 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-151-39205· OSTI ID:7352923

Koller, L D; Exon, J H; Roan, J G

Mice were given single doses of 4 mg of lead or 0.15 mg of cadmium, either intraperitoneally (IP) or orally by intubation. Eight hours later all mice were inoculated IP with 0.2 ml of a 2 percent suspension of sheep red blood cells (SRBC). Mice from each group were killed on days 3-6 to measure primary immune response (19s or IgM antibody) and on days 8-11 for the secondary response (7s or IgG antibody) after a second inoculation of SRBC on day 7. Lead administered orally or IP stimulated IgM antibody. Cadmium caused an increase in IgM when injected IP but resulted in a slight decrease when given orally. Lead, orally or IP, significantly reduced IgG antibody, but the IgG response decreased only when cadmium was given orally, and increased when injected IP. (JTE)

• Research Organization: Oregon State Univ., Corvallis
• OSTI ID: 7352923
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 151:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODY FORMATION
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
CADMIUM
ELEMENTS
INHIBITION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LEAD
MAMMALS
METALS
MICE
ORAL ADMINISTRATION
RODENTS
STIMULATION
VERTEBRATES