Humoral immune response of mice injected with tocopherol after exposure to X-radiation

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Immunopharmacol. Immunotoxicol.; (United States)

DOI:https://doi.org/10.3109/08923978709035201· OSTI ID:6856254

Roy, R M; Petrella, M

Serum haemagglutination (HA) titers have been determined for irradiated and non-irradiated mice responding to injection of two different concentrations of sheep red blood cells (SRBC) 24 to 48 hours after irradiation and immediate intraperitoneal injection of 2.5 mg DL alpha-tocopherol, the emulsifying vehicle, or saline. Mice maintained on tocopherol-deficient diets for 8 weeks post-weaning and those on regular diets exhibited increased IgG titers during peak response when injected with vitamin E. This partially alleviated the radiation-depression of the primary immune response induced by the smaller SRBC injection. This stimulatory effect was most significant in mice maintained on vitamin E-deficient diets. The HA titers of irradiated and non-irradiated mice maintained on normal rations were determined following a 10-fold increase in the SRBC inoculation. Antibody titer was greater following injection of the higher concentration of SRBC but post-irradiation injection of tocopherol immediately or 24 hours after irradiation did not enhance immune response. At the higher SRBC concentration maximum observed HA titers decreased with increasing dose of radiation; however, tocopherol had no significant dose-reducing effect. Tocopherol toxicity as manifested by depressed HA titers was observed occasionally in non-irradiated mice challenged with the higher concentration of SRBC.

• Research Organization: Concordia Univ., Montreal (Canada)
• OSTI ID: 6856254
• Journal Information: Immunopharmacol. Immunotoxicol.; (United States), Journal Name: Immunopharmacol. Immunotoxicol.; (United States) Vol. 9:1; ISSN IITOE
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMALS
ANTIBODIES
ANTIBODY FORMATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
HEMAGGLUTININS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
IONIZING RADIATIONS
MAMMALS
MATERIALS
MICE
NUTRITIONAL DEFICIENCY
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS
X RADIATION