Humoral immunodepression following acute NO/sub 2/ exposure in normal and adrenalectomized mice
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
The effects following 20 ppm NO/sub 2/ exposure on humoral immunity were investigated in C57BI/6 mice after 48, 72, and 96 h exposure. Both spleen plaque-forming cell (PFC) responses and serum hemagglutinins (HA) using sheep red blood cells (SRBC) as antigen were studied. Splenic and thymic weight and cellularity decreased on acute exposure to NO/sub 2/. PFC were markedly depressed after 48 h exposure and continued to decrease as exposure time was lengthened. HA titers were also depressed. The same significant suppression of PFC and HA titers was observed in adrenalectomized mice after 96 h NO/sub 2/ exposure. The depression of humoral immunity in NO/sub 2/-exposed mice was independent of stress-induced endogeneous steroids.
- Research Organization:
- INSERM Hospital Claude Bernard, Paris, France
- OSTI ID:
- 5353161
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 15:1; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHALCOGENIDES
DATA
DOSE-RESPONSE RELATIONSHIPS
ERYTHROCYTES
EXPERIMENTAL DATA
HEMAGGLUTININS
HORMONES
IMMUNITY
IMMUNOSUPPRESSION
INFORMATION
INHALATION
INTAKE
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
RODENTS
SPLEEN
STEROID HORMONES
THYMUS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHALCOGENIDES
DATA
DOSE-RESPONSE RELATIONSHIPS
ERYTHROCYTES
EXPERIMENTAL DATA
HEMAGGLUTININS
HORMONES
IMMUNITY
IMMUNOSUPPRESSION
INFORMATION
INHALATION
INTAKE
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
RODENTS
SPLEEN
STEROID HORMONES
THYMUS
TOXICITY
VERTEBRATES