Evidence for humoral immunodepression in NO/sub 2/-exposed mice: influence of food restriction and stress
Journal Article
·
· Environ. Res.; (United States)
OSTI ID:6065007
The effects of food restriction or 20 ppm NO/sub 2/ exposure on humoral immunity were investigated in normal and adrenalectomized C/sub 57/B1/6 mice. The thymic and splenic weights of sham-operated mice were similarly diminished after 4 days of NO/sub 2/ exposure or 4 days of food depletion. The responses of corresponding adrenalectomized mice were less depressed. Undernutrition induced lymphoid organ involution and corticosteroids were partly involved. Plaque-forming cells (PFC) per spleen and per 10/sup 6/ cells were markedly depressed after 4 days of NO/sub 2/ exposure, but less so after food deprivation. The same significant suppression of PFC was observed in adrenalectomized groups. Depression of humoral immunity was independent of stress-induced endogenous steroids. Moreover, NO/sub 2/ had a specific effect on humoral immunodepression, food restriction being an associated factor.
- Research Organization:
- INSERM, Paris, France
- OSTI ID:
- 6065007
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 42:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Humoral immunodepression following acute NO/sub 2/ exposure in normal and adrenalectomized mice
Immune potentiation after fractionated exposure to very low doses of ionizing radiation and/or caloric restriction in autoimmune-prone and normal C57Bl/6 mice
Radiofrequency radiation alters the immune system: modulation of T- and B-lymphocyte levels and cell-mediated immunocompetence by hyperthermic radiation. [26 MHz; 2/sup 0/C increase in core temperature of mice]
Journal Article
·
Mon Dec 31 23:00:00 EST 1984
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:5353161
Immune potentiation after fractionated exposure to very low doses of ionizing radiation and/or caloric restriction in autoimmune-prone and normal C57Bl/6 mice
Journal Article
·
Fri Jun 01 00:00:00 EDT 1990
· Clinical Immunology and Immunopathology; (USA)
·
OSTI ID:6748703
Radiofrequency radiation alters the immune system: modulation of T- and B-lymphocyte levels and cell-mediated immunocompetence by hyperthermic radiation. [26 MHz; 2/sup 0/C increase in core temperature of mice]
Journal Article
·
Sun Dec 31 23:00:00 EST 1978
· Radiat. Res.; (United States)
·
OSTI ID:6368408
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
CHALCOGENIDES
IMMUNITY
IMMUNOSUPPRESSION
LYMPHATIC SYSTEM
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUTRITIONAL DEFICIENCY
ORGANS
OXIDES
OXYGEN COMPOUNDS
RODENTS
SPLEEN
THYMUS
VERTEBRATES
WEIGHT
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
CHALCOGENIDES
IMMUNITY
IMMUNOSUPPRESSION
LYMPHATIC SYSTEM
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUTRITIONAL DEFICIENCY
ORGANS
OXIDES
OXYGEN COMPOUNDS
RODENTS
SPLEEN
THYMUS
VERTEBRATES
WEIGHT