Effect of methylmercury on humoral immune responses in mice under conditions simulated to practical situations

Journal Article · Sun Feb 01 04:00:00 EST 1976 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01685157· OSTI ID:7337368

Ohi, G; Fukuda, M; Seto, H; Yagyu, H

Methylmercury chloride was administered orally by intubation to 3 groups of male mice in concentrations of 0, 0.34, and 3.4 mg/kg for 5 consecutive days. Twenty-four hours after the last dose the mice were intraperitoneally injected with sheep erythrocytes (SRBC). Three groups of female mice were placed on diets containing 0, 0.5, and 5.0 ppM methylmercury at the time of mating, and were maintained on the diet during pregnancy and lactation. Weaned male mice were maintained on the diet for an additional 6 weeks then were injected with SRBC. Inhibition of the immune response was noted with the larger doses administered in a short period of time. Less definitive results were obtained with subchronic administration of low levels of methylmercury. (JTE)

• Research Organization: Dept. of Environmental Medicine, Tokyo
• OSTI ID: 7337368
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 15:2; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODY FORMATION
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
DIET
INGESTION
INHIBITION
INTAKE
MAMMALS
METHYLMERCURY
MICE
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PREGNANCY
PROGENY
RODENTS
VERTEBRATES