Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Radiation chemistry of nucleotides: 8,5'-cyclonucleotide formation and phosphate release initiated by hydroxyl radical attack on adenosine monophosphates

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574372· OSTI ID:7352712
; ;
The formation of 8,5'-cycloadenosine 5'-monophosphate (8,5'/sup -/ cloAMP) in irradiated solutions of adenosine 5'-monophosphate (5'-AMP) has been quantified over the pH range 2 to 10. Maxima for G(8,5'-cycloAMP) occur at pH 3 and 9 in nitrogen- and nitrous oxide-saturated solution. Oxygen completely inhibits the formation of 8,5'-cycloAMP. Over the pH range 3 to 10, G(8,5'-cycloAMP) is approximately equal to G(inorganic phosphate) for 5'-AMP. The pH response of both G(inorganic phosphate) and G(8,5'-cycloAMP) appears to be determined primarily by the reactivity of the various charged forms of the nucleotides to hydroxyl radical attack. (auth)
Research Organization:
Atomic Energy of Canada Ltd., Pinawa, Manitoba
OSTI ID:
7352712
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 65:3; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Distribution of damage in irradiated 5'-AMP: 8,5'-cyclo-AMP, 8-hydroxy-AMP, and adenine release
Journal Article · Wed May 01 00:00:00 EDT 1985 · Radiat. Res.; (United States) · OSTI ID:5490180
Immunochemical probe for 8,5'-cycloadenosine-5'-monophosphate and its deoxy analog in irradiated nucleic acids
Journal Article · Sat Nov 30 23:00:00 EST 1985 · Radiat. Res.; (United States) · OSTI ID:5804142
Oxygen dependence of product formation in irradiated adenosine 5'-monophosphate
Journal Article · Mon Feb 29 23:00:00 EST 1988 · Radiat. Res.; (United States) · OSTI ID:5200004

Related Subjects

560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMISTRY
COBALT 60
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
G VALUE
GAMMA RADIATION
HYDROXYL RADICALS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PH VALUE
RADIATION CHEMISTRY
RADIATIONS
RADICALS
RADIOISOTOPES
YEARS LIVING RADIOISOTOPES