Oxygen dependence of product formation in irradiated adenosine 5'-monophosphate

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577242· OSTI ID:5200004

Fuciarelli, A F; Koch, C J; Raleigh, J A

The formation of (R)- and (S)-8,5'-cycloadenosine 5'-monophosphate (8,5'-cycloAMP), 8-hydroxyadenosine 5'-monophosphate (8-hydroxyAMP), and radiolytic adenine release from irradiated solutions of adenosine 5'-monophosphate (5'-AMP) was measured as a function of increasing liquid-phase oxygen concentration. Three classes of specific molecular damage were identified on the basis of the oxygen dependence for product formation. Major changes in product yield occurred near the range of oxygen concentrations associated with the radiobiological oxygen effect. In addition to these data, systematic increases in the concentration of hydrogen peroxide at the time of irradiation resulted in an increase in the yield of 8-hydroxyAMP and a component of radiolytic adenine release in nitrogen-saturated solutions of 5'-AMP. However, no changes in the yield of the 8,5'-cyclonucleotides were observed under these conditions.

• Research Organization: Cross Cancer Institute, Edmonton, Alberta (Canada)
• OSTI ID: 5200004
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 113:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENINES
AMINES
AMP
ANTIMETABOLITES
AROMATICS
AZAARENES
BIOSYNTHESIS
CHEMICAL RADIATION EFFECTS
CHEMISTRY
DISPERSIONS
DRUGS
ELEMENTS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
IRRADIATION
MIXTURES
NONMETALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
OXYGEN COMPOUNDS
PEROXIDES
PURINES
RADIATION CHEMISTRY
RADIATION EFFECTS
SOLUTIONS
SYNTHESIS