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Distribution of damage in irradiated 5'-AMP: 8,5'-cyclo-AMP, 8-hydroxy-AMP, and adenine release

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576463· OSTI ID:5490180
;
The yields of 8,5'-cycloadenosine-5'-monophosphate, 8-hydroxyadenosine-5'-monophosphate, and adenine release have been measured in aqueous solutions of adenosine-5'-monophosphate (5'-AMP) irradiated under nitrous oxide. The yields are strongly pH dependent in a way which reflects the pK/sub a/'s of ionizable groups within 5'-AMP. Redistribution of hydroxyl radical attack between base and ribose moieties appears to be occurring in response to changes in the acid-base equilibria of 5'-AMP. Other pH-dependent phenomena which only indirectly reflect the pK/sub a/'s of 5'-AMP include the result that the yield of the (R) epimer of 8,5'-cycloadenosine-5'-monophosphate predominates at low pH while that of the (S) epimer predominates at high pH.
Research Organization:
Cross Cancer Institute, Edmonton, Alberta
OSTI ID:
5490180
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600* -- Radiation Chemistry
ADENINES
AMINES
AMP
ANTIMETABOLITES
AQUEOUS SOLUTIONS
AROMATICS
AZAARENES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CHROMATOGRAPHY
COBALT 60
COBALT ISOTOPES
DECOMPOSITION
DISPERSIONS
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXYL RADICALS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIQUID COLUMN CHROMATOGRAPHY
MAGNETIC RESONANCE
MINUTES LIVING RADIOISOTOPES
MIXTURES
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
NUCLEAR MAGNETIC RESONANCE
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PH VALUE
PURINES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOISOTOPES
RADIOLYSIS
RESONANCE
SEPARATION PROCESSES
SOLUTIONS
YEARS LIVING RADIOISOTOPES