Delayed erythropoiesis in irradiated rats grafted with syngeneic marrow: effects of cytotoxic drugs and iron-deficiency anemia. [Gamma radiation; cyclophosphamide; busulfan; dimethylmyleran]
Journal Article
·
· Blood; (United States)
OSTI ID:7351012
Erythropoiesis in spleens of lethally irradiated Lewis rats grafted with 4-35 x 10/sup 6/ syngeneic marrow cells was inhibited or delayed during the test period of 5 days; this was in marked contrast to observations in irradiated mice. The mechanism of this inhibition was the subject of this study. Pretreatment of recipients 9 days prior to irradiation with the cytotoxic drugs cyclophosphamide (CY), busulfan (BUS), or dimethylmyleran (DMM), or the induction of iron deficiency with anemia in recipients reversed this delayed erythropoiesis. However, neither iron-deficiency anemia nor pretreatment with BUS or DMM affected the ability of irradiated recipients to reject 20 to 50 x 10/sup 6/ allogeneic marrow cells. The administration of commercial preparations of erythropoietin to hosts stimulated erythropoiesis moderately. However, proliferation of syngeneic marrow cells was not enhanced when infused into lethally irradiated spontaneous hypertensive (SH) inbred-strain rats which have high levels of endogenous erythropoietin. Finally, plasma from irradiated rats treated with phenylhydrazine to produce severe anemia was rich in erythropoietin but failed to stimulate erythropoiesis in the cell transfer system. Two hypotheses are considered.
- Research Organization:
- Boston Univ.
- OSTI ID:
- 7351012
- Journal Information:
- Blood; (United States), Journal Name: Blood; (United States) Vol. 48:3; ISSN BLOOA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Migration of hemopoietic stem cells and B lymphocytes from bone marrow to the spleen in the presence of phenylhydrazine-induced anemia. [Mice]
Transient engraftment of syngeneic bone marrow after conditioning with high-dose cyclophosphamide and thoracoabdominal irradiation in a patient with aplastic anemia
Marrow transplantation in the treatment of a murine heritable hemolytic anemia
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:5705283
Transient engraftment of syngeneic bone marrow after conditioning with high-dose cyclophosphamide and thoracoabdominal irradiation in a patient with aplastic anemia
Journal Article
·
Sun Dec 31 23:00:00 EST 1989
· American Journal of Hematology; (USA)
·
OSTI ID:7018631
Marrow transplantation in the treatment of a murine heritable hemolytic anemia
Journal Article
·
Mon May 15 00:00:00 EDT 1989
· Blood; (United States)
·
OSTI ID:5901496
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANEMIAS
ANIMALS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENDOXAN
ERYTHROPOIESIS
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IONIZING RADIATIONS
IRON
MAMMALS
METALS
MICE
MYLERAN
NUTRITIONAL DEFICIENCY
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SPLEEN
SYMPTOMS
TISSUES
TRANSITION ELEMENTS
TRANSPLANTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANEMIAS
ANIMALS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENDOXAN
ERYTHROPOIESIS
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IONIZING RADIATIONS
IRON
MAMMALS
METALS
MICE
MYLERAN
NUTRITIONAL DEFICIENCY
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SPLEEN
SYMPTOMS
TISSUES
TRANSITION ELEMENTS
TRANSPLANTS
VERTEBRATES