Migration of hemopoietic stem cells and B lymphocytes from bone marrow to the spleen in the presence of phenylhydrazine-induced anemia. [Mice]

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5705283

Kozlov, V A; Lozovoi, V P; Zhuravkin, I N

The effect of phenylhydrazine-induced anemia on processes of migration of polypotent hematopoietic stem cells (PHSC) and B cells from bone marrow to the spleen was studied. CBA mice were given phenylhydrazine hydrochloride 3 times at the rate of 1.2 mg/mouse on -3, -2, and 0 days. The mice develop marked anemia. The most intensive migration was observed on the first day after the last injection. On the 4th and 7th day after the last injection of phenylhydrazine, migration of PHSC exceeded the level obtained in control animals by 9 and 4 times, respectively. On the 1st and 4th days after the last injection of phenylhydrazine there was more intensive migration of B cells from bone marrow to the spleen. However, there was a sharp decrease in migration of B cells on the 7th day after the last phenylhydrazine injection. The data are apparently indicative of the fact that stimulation of erythropoiesis by means of phenylhydrazine stimulates migration of both PHSC and B cells from bone marrow to the spleen. That migration of PHSC from bone marrow is the chief mechanism of increase in content thereof in the spleen is confirmed. It may be assumed that intensification of PHSC migration is attributable to elevation of the level of endogenous erythropoietin. The data indicate that stimulation of erythropoiesis in the presence of phenylhydrazine-induced anemia leads to greater migration of cells of the nonerythropoietic population, in particular, B lymphocytes. It may also be assumed that, in the presence of erythroid hyperplasia, cells referable to other classes of hemopoiesis are ejected from bone marrow, including the precursors of immunocompetent cells B lymphocytes, which then settle in the spleen. However, the possibility of a direct effect of erythropoietin on B cells cannot be ruled out. (ERB)

• Research Organization: Inst. of Clinical and Experimental Medicine, Novosibirsk, USSR
• OSTI ID: 5705283
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:2; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ERYTHROPOIESIS
ERYTHROPOIETIN
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MIGRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RODENTS
SOMATIC CELLS
SPLEEN
STEM CELLS
SYMPTOMS
TISSUES
VERTEBRATES