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Effect of chronic hypoxia and erythropoietin on migration of hemopoietic stem cells from bone marrow to the spleen

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5388423
; ;
It is known that keeping mice in a pressure chamber at low pressure for a long period of time leads to an increase in erythrocyte content of blood which results in depression of erythropoiesis in such mice after they are returned to normal conditions, due to a drop in level of endogenous erythropoietin. It has now been firmly established that erythropoietin plays the leading role in regulation of erythropoiesis, although the question of whether hemopoietic stem cells (HSC) are a target for this hormone is still debatable. In this work, the effect of posthypoxic polycythemia and administration of exogenous erythropoietin on the process of HSC migration from bone marrow into the spleen was investigated.
Research Organization:
Inst. of Clinical and Experimental Medicine, Novosibirsk, USSR
OSTI ID:
5388423
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:4; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ERYTHROPOIESIS
ERYTHROPOIETIN
EXPERIMENTAL DATA
GRAPHS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INFORMATION
IONIZING RADIATIONS
LOW PRESSURE
MAMMALS
MICE
NUMERICAL DATA
ORGANS
POLYCYTHEMIA
PRESSURE DEPENDENCE
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN
STEM CELLS
TISSUES
TRANSLOCATION
VERTEBRATES
X RADIATION