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Transient engraftment of syngeneic bone marrow after conditioning with high-dose cyclophosphamide and thoracoabdominal irradiation in a patient with aplastic anemia

Journal Article · · American Journal of Hematology; (USA)
; ; ; ; ; ; ;  [1]
  1. Kanazawa Univ. Hospital (Japan)
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We describe the clinical course of a 16 year old girl with aplastic anemia who was treated by syngeneic bone marrow transplantation. Engraftment was not obtained by simple infusion of bone marrow without immunosuppression. The patient received a high-dose cyclophosphamide and thoracoabdominal irradiation, followed by second marrow transplantation from the same donor. Incomplete but significant hematologic recovery was observed; however, marrow failure recurred 5 months after transplantation. Since donor and recipient pairs were genotypically identical, graft failure could not be attributed to immunological reactivity of recipient cells to donor non-HLA antigens. This case report implies that graft failure in some cases of aplastic anemia might be mediated by inhibitory cells resistant to cyclophosphamide and irradiation.
OSTI ID:
7018631
Journal Information:
American Journal of Hematology; (USA), Journal Name: American Journal of Hematology; (USA) Vol. 33:1; ISSN 0361-8609; ISSN AJHED
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
ANEMIAS
ANIMAL TISSUES
ANTINEOPLASTIC DRUGS
BODY
BODY AREAS
BONE MARROW
COMBINED THERAPY
DISEASES
DRUGS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
ORGANS
SURVIVAL TIME
SYMPTOMS
THERAPY
TISSUES
TRANSPLANTS