Total lymphoid irradiation and cyclophosphamide conditioning prior to bone marrow transplantation for patients with severe aplastic anemia

Journal Article · Thu Sep 01 00:00:00 EDT 1983 · Blood; (United States)

OSTI ID:5577970

Ramsay, N K; Kim, T H; McGlave, P; Goldman, A; Nesbit, Jr, M E; Krivit, W; Woods, W G; Kersey, J H

A preparative regimen, consisting of total lymphoid irradiation and cyclophosphamide, was utilized in 40 patients with severe aplastic anemia undergoing allogeneic marrow transplantation. This regimen was successful in decreasing rejection in these previously transfused patients, as only one patient rejected the marrow graft. Twenty-nine of the 40 transplanted patients are surviving from 1.5 to 59 mo, with a median follow-up of 24 mo. The actuarial survival rate for these heavily transfused patients with aplastic anemia is 72% at 2 yr. This preparative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia. Future efforts in this area must be aimed at the elimination of graft-versus-host disease and control of fatal infections.

• Research Organization: Department of Pediatrics, University of Minnesota, Minneapolis
• OSTI ID: 5577970
• Journal Information: Blood; (United States), Journal Name: Blood; (United States) Vol. 62:3; ISSN BLOOA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADOLESCENTS
AGE GROUPS
ANEMIAS
ANIMAL TISSUES
BODY
BONE MARROW
CHILDREN
DISEASES
FEMALES
FIBROSIS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNOSUPPRESSION
INFANTS
LYMPHATIC SYSTEM
MALES
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIOINDUCTION
SYMPTOMS
TISSUES
TRANSPLANTS