Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6882557
Six patients with aplastic anemia underwent bone marrow transplantation following conditioning with high dose cyclophosphamide and single dose total lymphoid irradiation with 750 rad, 26 rad/min at the midplane of the patient. They all received bone marrow from human leukocyte antigens/mixed lymphocyte culture (HLA/MLC) matched siblings. Five of 6 patients were alive without complications at 12, 11, 7, 4 and 4 months respectively. The remaining patient died from sepis which he had prior to transplantation. There were no graft rejection, graft-vs-Host Disease (GVHD) or interstitial pneumonitis among these patients. The procedure was well tolerated with minimal side effects. The results will be compared with those of groups whose bone marrow was previously transplanted with different immunosuppressive methods.
- Research Organization:
- Univ. of Minnesota, Minneapolis
- OSTI ID:
- 6882557
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:7
- Country of Publication:
- United States
- Language:
- English
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Journal Article
·
Sun Dec 31 23:00:00 EST 1989
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·
OSTI ID:7018631
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·
Thu Sep 01 00:00:00 EDT 1983
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·
OSTI ID:5577970
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Journal Article
·
Wed Jun 01 00:00:00 EDT 1988
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6908254
Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ALKYLATING AGENTS
ANEMIAS
ANIMAL TISSUES
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DISEASES
DOSES
DRUGS
ENDOXAN
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNOSUPPRESSION
IRRADIATION
LINEAR ACCELERATORS
LYMPHATIC SYSTEM
ORGANS
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ALKYLATING AGENTS
ANEMIAS
ANIMAL TISSUES
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DISEASES
DOSES
DRUGS
ENDOXAN
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNOSUPPRESSION
IRRADIATION
LINEAR ACCELERATORS
LYMPHATIC SYSTEM
ORGANS
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION