Bone marrow scanning with /sup 52/Fe. Regeneration and extension of marrow after ablative doses of radiotherapy

Journal Article · Mon Mar 01 04:00:00 EST 1976 · Cancer; (United States)

OSTI ID:7349076

Knospe, W H; Rayudu, V M.S.; Cardello, M; Friedman, A M; Fordham, E W

Extensively irradiated patients were studied from 0 to 73 months after irradiation by /sup 52/Fe bone marrow scanning. Marrow regeneration was observed in most patients after intervals of 12 months or longer. The degree of recovery was not dose-related and the marrow ablative dose was not defined with doses of 4000-5000 rads. Degree of recovery depended more upon the antomic region and/or sequence of fields treated; the last field treated invariably showed poorer regeneration when recovery was uneven. Active erythropoiesis expanded into distal inactive erythropoietic sites from 3 to 12 months after irradiation and then decreased thereafter. Blood count cytopenias were almost always restricted to the first year after irradiation.

• Research Organization: Rush-Presbyterian-St. Luke's Medical Center, Chicago
• NSA Number: NSA-33-29902
• OSTI ID: 7349076
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 37:3; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BLOOD FORMATION
BODY
BONE MARROW
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROPOIESIS
EVEN-EVEN NUCLEI
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRON 52
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECOVERY
SCINTISCANNING
THERAPY
TISSUES
TRACER TECHNIQUES