Late effects on human bone marrow after extended field radiotherapy

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90261-4· OSTI ID:5311841

Parmentier, C; Morardet, N; Tubiana, M

Thirty-two patients with lymphoma were treated by extended radiotherapy (RT) at a dose of 40 Gy and were studied by ferrokinetic studies and surface counting at various times following irradiation. Loss of hematopoietic activity in the irradiated areas is compensated by increased activity in the non-irradiated areas. Despite the return of peripheral blood counts to normal, the hyperactivity of the non-irradiated bone marrow persists over up to 13 years after RT, while the hematopoietic activity of the irradiated areas remains depressed and is only slightly higher than immediately after RT. The hypoactivity persisted even when the hemopoietic tissues had been subjected to the intense stimulation provoked by an aplasia caused by chemotherapy. However, a recovery was observed for dose of 20 Gy or lower. The hemopoietic activity of the irradiated bone marrow appears to be related to the volume of the marrow irradiated and is higher after a mantle + inverted Y field than after a mantle field. Bone marrow scintigraphies with /sup 59/Fe in 7 out of 9 patients studied revealed an extension of hematopoiesis into a normally dormant area of the marrow, such as the femora. In 2 patients an erythropoietic activity was observed in spleens which had received a dose of 40 Gy, and extra medullary erythropoiesis was found in approximately two-thirds of the patients.

• Research Organization: Institut Gustave, Roussy, Villejuif France
• OSTI ID: 5311841
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 9:9; ISSN IOBPD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD COUNT
BLOOD FORMATION
BODY
BONE MARROW
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DISEASES
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
IRRADIATION
ISOTOPES
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ORGANS
PARTIAL BODY IRRADIATION
PATIENTS
PHYSIOLOGY
RADIATION EFFECTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SCINTISCANNING
SIDE EFFECTS
THERAPY
TISSUES