Bone marrow scanning with $sup 52$Fe. Regeneration and extension of marrow after ablative doses of radiotherapy

Journal Article · Mon Mar 01 04:00:00 EST 1976 · Cancer, v. 37, no. 3, pp. 1432-1442

OSTI ID:4042706

Knospe, W H; Rayudu, V M.S.; Cardello, M; Friedman, A M; Fordham, E W

Extensively irradiated patients were studied from 0 to 73 months after irradiation by $sup 52$Fe bone marrow scanning. Marrow regeneration was observed in most patients after intervals of 12 months or longer. The degree of recovery was not dose-related and the marrow ablative dose was not defined with doses of 4000-5000 rads. Degree of recovery depended more upon the antomic region and/or sequence of fields treated; the last field treated invariably showed poorer regeneration when recovery was uneven. Active erythropoiesis expanded into distal inactive erythropoietic sites from 3 to 12 months after irradiation and then decreased thereafter. Blood count cytopenias were almost always restricted to the first year after irradiation.

• Research Organization: Rush-Presbyterian-St. Luke's Medical Center, Chicago
• NSA Number: NSA-33-029902
• OSTI ID: 4042706
• Journal Information: Cancer, v. 37, no. 3, pp. 1432-1442, Journal Name: Cancer, v. 37, no. 3, pp. 1432-1442; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

*BONE MARROW-- SCINTISCANNING
*SCINTISCANNING-- IRON 52
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
BIOLOGICAL REGENERATION
DOSE-RESPONSE RELATIONSHIPS
ERYTHROPOIESIS
N48830* --Life Sciences--New Tracer Techniques--Other
PATIENTS
RADIOTHERAPY
TRACER TECHNIQUES