Bone marrow regeneration from cortex following segmental fractionated irradiation. [X Radiation]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(77)90005-0· OSTI ID:7077372

Rubin, P; Elbadawi, N A; Thomson, R A.E.; Cooper, Jr, R A

Following fractionated, segmental irradiation of long bones at doses from 2000 to 5000 rad, bone marrow regeneration occurs first in the cortex and along the endosteum with the central marrow cavity being repopulated in a centripetal fashion. When the radiation is fractionated at a rate of 200 rad daily and 1000 rad weekly, the time course of regeneration is dose dependent, and involves equally the myeloid and erythroid compartments. With 2000 and 3000 rad, cortical regeneration is first observed at three months post-irradiation; while with doses of 4000 to 5000 rad, cortical recovery does not occur before 6 months. The identification of cortex as the site of initial recovery following fractionated, segmental irradiation explains the discrepancy between /sup 59/Fe uptake, as a measure of erythropoiesis, and medullary bone marrow hypocellularity. In addition, the present studies support the concept that bone marrow regeneration following segmental irradiation occurs by heterotypic conversion of uncommitted mesenchymal cells resident in the cortex and not by circulating stem cell repopulation.

• Research Organization: Univ. of Rochester Cancer Center, NY
• OSTI ID: 7077372
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 2:1/2; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BLOOD FORMATION
BODY
BONE MARROW
BONE TISSUES
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRON 59
IRON ISOTOPES
IRRADIATION
ISOTOPES
NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
TISSUES
UPTAKE
X RADIATION